Curcuma longa extract, turmeric root powder curcumin 2-95%

Curcumin, is an anti-inflammatory molecule in the turmeric root, a relative of ginger. Turmeric has been used for thousands of years as a medicinal preparation and a preservative and coloring agent in foods. Curcumin was isolated as the major yellow pigment in turmeric; chemically diferulomethane, and has a polyphenolic molecular structure similar to other plant pigments (eg. extracted from grapes in wine (resveratrol), or in green tea (catechins) or in certain fruit juices (blueberries, strawberries, pomegranates etc.) This polyphenols share in common anti-oxidant and anti-inflammatory properties with associated health benefits

Can eating turmeric-based curries, increase curcumin levels in the blood?

India has a low incidence and prevalance of Alzheimer's, which may be related to genetics or a particular intake of specific foods. Some people attribute the low incidence of Alzheimer's to a high intake of turmeric in Asia. As turmeric contains an average of 5-10% curcumin, the daily intake of curcumin is approximated in India is thought be about 125 mg. Importantly incooking curries, curcumin is often dissolved and extracted into fat, eg. ghee, which may increase its bioavailability. Animal studies have demonstrated that the way it is administered affects its distribution in the body. Unformulated curcumin, such as purified and dried curcumin in a capsule, is absorbed easily but the liver and GI tract tag it in a way that make it not very bioavailable to the brain. There is a lot of confusion about curcumin bioavailability versus absorption. Curcumin is absorbed, but not necessarily bioavailable. Further GI and liver glucuronidation or sulfation "tagged curcumin" which interfere with bioavailability it some tissues also leadds to its rapid removal by the kidneys. Unliked tagged curcumin, free curcumin readily crossed the blood brain barrier and is relatively stable.

To increase free curcumin and its half life, one company Sabinsa has used the strategy to reduce curcumin's clearance by inhibiting glucuronidation using piperine (Sabinsa C3 complex). Glucuronidation is a method to to rid the body of toxins and remove metabolized drugs. Therefore one should determine blood levels of currently used medications after taking this formulation for several days.

Other proposed strategies are to increase its solubility (Meriva), or to encapsulate and protect it from hydrolysis and to control where in the intestine it is absorbed (Longvida).

In summary curcumin is easily absorbed but not necessarily very bioavailable to the brain (such as dissolved in cooking oils or formulated). It is stable in fatty tissues such as the brain, but not in blood.

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